Four New Lignans with a Bicyclo[3.3.1]nonadienemethanol Skeleton from Cunninghamia lanceolata |
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| Authors: | Ching‐Kuo Lee Ming‐Hsi Yeh Tzong‐Huei Lee His‐Lin Chiu Yueh‐Hsiung Kuo |
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| Affiliation: | 1. School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan, R.O.C.;2. Department of Chemistry, National Taiwan University, Taipei 106, Taiwan, R.O.C. (phone: +886‐2‐33661671;3. fax: +886‐2‐23636359);4. Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan, R.O.C.;5. Agricultural Biotechnology Research Center, Academia Sinica, 115 Taipei, Taiwan, R.O.C. |
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| Abstract: | Four unique bicyclo[3.3.1]nonadienemethanol lignans, designated lanceolatanins A ( 1 ), B ( 2 ), C ( 3 ), and D ( 4 ), along with one previously known compound, isolariciresinol ( 5 ), were isolated from the MeOH extracts of the heartwood of Cunninghamia lanceolata. Their structures were elucidated by application of various spectroscopic methods, including 1D‐ and 2D‐NMR techniques, to their acetylated derivatives 1a, 2a, 3a , and 4a . Their possible biosynthetic formations are also discussed. |
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| Keywords: | Cunninghamia lanceolata Bicyclo[3.3.1]nonadienemethanol lignans Lignans Lanceolatanins A – D |
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