Synthesis and Crystal Structures of Two 9‐(2‐Bromoethyl)‐Substituted 7‐Deazapurines |
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| Authors: | Simona Asaftei Martin Reichelt Hans Reuter Helmut Rosemeyer |
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| Institution: | 1. Organic Materials Chemistry/Bioorganic Chemistry, Institute of Chemistry, University of Osnabrück, Barbarastr. 7, D‐49069 Osnabrück;2. Inorganic Chemistry/Structure Chemistry, Institute of Chemistry, University of Osnabrück, Barbarastr. 7, D‐49069 Osnabrück |
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| Abstract: | The 7‐(2‐bromoethyl) derivatives, 2a and 2b , of 4‐chloro‐7H‐pyrrolo2,3‐d]pyrimidine ( 1a ) and 4‐chloro‐7H‐pyrrolo2,3‐d]pyrimidin‐2‐amine ( 1b ) were synthesized by nucleobase anion alkylation (NaH, DMF) and crystallized. X‐Ray analyses of both compounds were performed, and they revealed significantly different positioning of the side chain relative to the heterocyclic ring, depending on the substituent (H or NH2) at C(2). |
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| Keywords: | 7‐Deazapurines Purines Pyrrolo[2 3‐d]pyrimidines X‐Ray crystallography |
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