Synthesis of Deuterium‐Labeled Perfume Ingredients as Internal Standards for Their GC/MS Quantification |
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| Authors: | Christian Chapuis Carole Cantatore Peter Fankhauser René Challand Jean‐Jacques Riedhauser |
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| Institution: | 1. Firmenich SA, Corporate R&D Division, P.?O. Box 239, CH‐1211 Geneva 8, (phone: +41‐22‐7803610;2. fax: +41‐22‐7803334) |
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| Abstract: | The synthesis of various D‐labeled perfume ingredients (orris‐like, sandalwood‐like, musky, and amber‐like) is presented. These substances, possessing practically identical H2O/solid and solid/gas partition coefficients as their unlabeled analogues, are used as internal standards for the validation of a new analytical GC/MS method for the determination of low residual concentrations in H2O after biodegradability tests. |
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| Keywords: | Perfume ingredients Biodegradability Lindlar catalyst L‐Selectride Deuterium labeling |
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