Comparative Studies of Different Quinolinone Derivatives as Donors in Fluorescence‐Resonance‐Energy Transfer (FRET) – Systems in Combination with a (Bathophenanthroline)ruthenium(II) Complex as Acceptor |
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| Authors: | Rolf A Kramer Roman Flehr Myriam Lay Michael U Kumke Willi Bannwarth |
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| Institution: | 1. Institut für Organische Chemie und Biochemie, Albert‐Ludwigs‐Universit?t Freiburg, Albertstr. 21, D‐79104 Freiburg (phone: +497612036073;2. fax: +497612038705);3. Institut für Chemie, Universit?t Potsdam, Karl‐Liebknecht‐Str. 24?–?25, D‐14476 Potsdam‐Golm, (phone: +493319775209) |
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| Abstract: | We describe the preparation as well as a detailed photophysical study of Fmoc‐amino acid building blocks carrying different carbostyril (=quinolin‐2(1H)‐one) heterocycles as donors in a FRET (fluorescence‐resonance‐energy transfer) system in combination with a RuII(bathophenanthroline)] complex (bathophenanthroline=4,7‐diphenyl‐1,10‐phenanthroline). The efforts resulted in a clear preference for building block 16 due to its ease of synthesis (Scheme 2), its chemical robustness, and the FRET efficiency when incorporated into peptides. |
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| Keywords: | Quinolinones Fluorescence‐resonance‐energy transfer (FRET) Ruthenium complexes Peptides Amino acids Carbostyril derivatives Bathophenanthroline complexes |
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