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Multicomponent Approach Towards the Synthesis of Substituted Pyrroles under Supramolecular Catalysis Using β‐Cyclodextrin as a Catalyst in Water Under Neutral Conditions |
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| Authors: | Sabbavarapu Narayana Murthy Bandaru Madhav Akkiligunta Vijay Kumar Kakulapati Rama Rao Yadavalli Venkata Durga Nageswar |
| Institution: | Organic Chemistry Division‐I, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500‐607, India (phone: +91?40?27160512) |
| Abstract: | Synthesis of substituted pyrroles in H2O by using β‐cyclodextrin as a supramolecular catalyst is described. This reaction has several advantages over existing methods and provides substituted pyrroles in good‐to‐excellent yields (79–89%). The supramolecular catalysis of the reaction was studied using 1H‐NMR spectroscopy. β‐Cyclodextrin can be recovered and reused several times without loss of activity. |
| Keywords: | β ‐Cyclodextrin Phenacyl bromide Acetylacetone Amines Supramolecular catalysis Multicomponent synthesis |