Synthesis of Novel Thioglycoside Derivatives Containing Quinazolinone |
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| Authors: | Hui Huang Jian‐Fang Gao Ling‐Hua Cao Duo‐Zhi Wang Jian‐Bin Zhang Shu‐Bao Zhou Yu‐Qiang Zhou |
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| Affiliation: | 1. College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi Xinjiang 830046, P. R. China;2. Physics and Chemistry Test Center of Xinjiang University, Urumqi 830046, P. R. China |
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| Abstract: | A series of novel thioglycoside derivatives containing 4(3H)‐quinazolinone was designed and synthesized from 2‐chloromethyl‐quinazolin‐4(3H)‐ones and 1‐thioglycose. Several 2‐chloromethyl‐quinazolin‐4(3H)‐ones were synthesized on refluxing with 2‐(chloroacetylamino)‐benzoic acid and arylamines in acetonitrile. All of the novel compounds were characterized by IR, 1H NMR spectra and elemental analysis. The structures of compounds 7b, 8b and 8c have been determined by X‐ray diffraction analysis. |
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| Keywords: | 4(3H)‐Quinazolinone Thioglycoside 1‐Thioglycose X‐ray diffraction |
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