Juncenolides H – K,New Briarane Diterpenoids from Junceella juncea |
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| Authors: | Shih‐Sheng Wang Yu‐Hui Chen Jiun‐Yang Chang Tsong‐Long Hwang Chung‐Hsiung Chen Ashraf Taha Khalil Ya‐Ching Shen |
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| Affiliation: | 1. Institute of Marine Biotechnology and Resources, National Sun Yat‐sen University, 70 Lien‐Hai Road, Kaohsiung, Taiwan 80424, R.O.C.;2. School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan 100, R.O.C. (phone: +886‐02‐3123456, ext. 62226;3. fax: +886‐02‐23919098);4. Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan, R.O.C. |
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| Abstract: | Chemical investigation of the Taiwanese gorgonian coral Junceella juncea resulted in the isolation of four new briarane‐type diterpenoids, juncenolides H, I, J, and K ( 1 – 4 ). Their structures were determined on the basis of spectroscopic analysis, especially 1‐ and 2D‐NMR. The inhibitory effects of compounds 1 – 4 on superoxide‐anion generation and elastase release by human neutrophils were evaluated. |
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| Keywords: | Junceella juncea Briarane diterpenes Diterpenes Juncenolides H – K Anti‐inflammatory activity |
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