Verticillane and Norverticillane Diterpenoids from the Formosan Soft Coral Cespitularia hypotentaculata |
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| Authors: | Jiun‐Yang Chang Mohamed H. Abd El‐Razek Ya‐Ching Shen |
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| Affiliation: | 1. Department of Marine Biotechnology and Resources, National Sun Yat‐Sen University, Kaohsiung 804, Taiwan, Republic of China;2. School of Pharmacy, College of Medicine, National Taiwan University, Jen‐Ai Rd. Sec.?1, Taipei 100, Taiwan, Republic of China, (phone: +886‐02‐3123456, ext 62226;3. fax: +886‐02‐23919098) |
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| Abstract: | Five new diterpenes, cespihypotins W–Z ( 1 – 4 , resp.) and cespihypotone ( 5 ) have been isolated from the AcOEt‐soluble fraction of the Formosan soft coral Cespitularia hypotentaculata. Two of them having the norverticillane skeleton, i.e., 1 and 2 , and the other three, 3 – 5 , possessing a verticillane skeleton. The structures were established as (+)‐(1βH,7E)‐6β,11β‐dihydroxynorverticilla‐4(18),7‐diene‐10,12‐dione ( 1 ), (+)‐(1βH,7E)‐6β‐acetoxy‐11β‐hydroxynorverticilla‐4(18),7‐diene‐10,12‐dione ( 2 ), (?)‐(1βH,7E)‐6β‐acetoxyverticilla‐4(18),7,11‐triene‐10,12‐γ‐lactone ( 3 ), (+)‐(1βH,7E)‐6β‐acetoxy‐10‐hydroxyverticilla‐4(18),7,11‐triene‐10,12‐γ‐lactone ( 4 ), and (+)‐(1βH,3Z)‐10β‐hydroxy‐6‐oxoverticilla‐3,11‐diene‐10,12‐γ‐lactone ( 5 ), respectively, on the basis of 1D‐ and 2D‐NMR spectroscopic analyses. |
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| Keywords: | Cespitularia hypotentaculata Cespihypotins W – Z Cespihypotone Diterpenes Verticillanes Norverticillanes Soft corals |
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