Ultrasound‐Assisted Wittig Reaction: A Short,Efficient Synthesis of 2‐Methoxy‐6‐Alkyl‐1,4‐Benzoquinones |
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| Authors: | Li‐Qiang Wu Chun‐Guang Yang Li‐Ming Yang Li‐Juan Yang |
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| Affiliation: | School of Pharmacy, Xinxiang Medical College, Xinxiang, Henan 453003, P. R. China |
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| Abstract: | A short, efficient synthesis of 2‐methoxy‐6‐alkyl‐1,4‐benzoquinones is described. Ultrasound‐assisted Wittig reaction of alkyltriphenyl phosphonium bromides with o‐vanillin in basic aqueous conditions followed by reduction with Na/n‐BuOH gave 2‐methoxy‐6‐alkylphenols. Oxidation of 2‐methoxy‐6‐alkylphenols with Fremy's salt produced the title compounds. |
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| Keywords: | 2‐Methoxy‐6‐alkyl‐1,4‐benzoquinones o‐Vanillin Wittig reaction Ultrasound irradiation |
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