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Brönsted Acidic Ionic Liquid as an Efficient Catalyst for Acetylation of Alcohols and Phenols |
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| Authors: | Abdol R. Hajipour Leila Khazdooz Arnold E. Ruoho |
| Affiliation: | 1. Dept. of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706‐1532, WI, USA;2. Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan 84156, IR, Iran |
| Abstract: | A novel Brönsted acidic room temperature ionic liquid (1‐H‐3‐methyl‐imidazolium bisulfate) is found to catalyze efficiently the acetylation of a wide rang of alcohols as well as phenols with acetic anhydride in good to excellent yields at 50°C under solvent‐free conditions. Products are easily isolated by extraction with ether and the protocol is mild and green, compared to the existing method based on toxic solvents. |
| Keywords: | Brö nsted acidic ionic liquid Acetylation Acohol Methylimidazolium hydrogen‐sulfate Solvent‐free conditions |