Novel and Highly Effective Method for the Trimethylsilylation of Alcohols and Phenols with Hexamethyldisilazane (HMDS), Catalyzed by I2 Generated in situ Using Fe(NO3)3⋅9 H2O/NaI under Heterogeneous and Neutral Conditions |
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| Authors: | Ardeshir Khazaei Sadegh Rahmati Amin Rostami |
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| Institution: | 1. Faculty of Chemistry, Bu‐Ali Sina University, P.O. Box 651783868, Hamadan, Iran;2. Department of Chemistry, Faculty of Science, University of Kurdistan, P.O. Box 6617715143, Sanandaj, Iran |
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| Abstract: | Structurally diverse alcohols and phenols were trimethylsilylated in a clean and efficient reaction with hexamethyldisilazane (HMDS) based on the use of I2 generated in situ from Fe(NO3)3?9 H2O/NaI. The reaction occurs very rapid in good‐to‐high yield in CH2Cl2 at room temperature, and the use of toxic and corrosive molecular I2 is avoided. |
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| Keywords: | Hexamethyldisilazane Catalysis Trimethylsilylation Protecting groups Heterogeneous catalysis Iodine generation |
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