New Diterpenoid Alkaloids from Aconitum recemulosum Franch. |
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| Authors: | Yong‐Hui Ge Shu‐Zhen Mu Shi‐Ying Yang Yang Lu Jian‐Xin Zhang Ye Wang Xiao‐Jiang Hao |
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| Institution: | 1. The Medicine College of Guizhou University, Guiyang 550002, P.?R. China;2. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, P.?R. China, (phone: +86‐851‐3804492;3. fax: +86‐851‐3805081);4. Institute of Materia Medica, Chinese Academy of Sciences, Beijing 100050, P.?R. China |
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| Abstract: | Two new diterpenoid alkaloids, racemulosines A ( 1 ) and B ( 2 ), were isolated from the roots of Aconitum racemulosum Franch . The structures of the new alkaloids were elucidated by analysis of physical and spectroscopic data, and the structure of 1 was further confirmed by a single‐crystal X‐ray diffraction analysis. Furthermore, compound 1 , at 2.25?10?4 mol/l, showed moderate activity against platelet aggregation induced by PAF (platelet‐activation factor). |
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| Keywords: | Aconitum racemulosum Diterpenoids Alkaloids Racemulosines A and B Inhibitory activities |
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