Bioactive Cytochalasins from Aspergillus flavipes,an Endophytic Fungus Associated with the Mangrove Plant Acanthus ilicifolius |
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| Authors: | Zhen‐Jian Lin Guo‐Jian Zhang Tian‐Jiao Zhu Rui Liu Hong‐Juan Wei Qian‐Qun Gu |
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| Institution: | 1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, P.?R. China, (phone: +86‐532‐82032065;2. fax: +86‐532‐82033054) |
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| Abstract: | Five new cytochalasins, Z16–Z20 ( 1 – 5 ), and three known ones, 6 – 8 , were isolated from Aspergillus flavipes, an endophytic fungus associated with Acanthus ilicifolius. Their structures were elucidated on the basis of comprehensive spectral analysis. Cytochalasin Z17 ( 2 ) and rosellichalasin ( 8 ) showed cytotoxic activities against A‐549 cell lines with IC50 values of 5.6 and 7.9 μM , respectively. |
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| Keywords: | Aspergillus flavipes Cytochalasins Z16 – Z20 Endophytic fungi Acanthus ilicifolius Cytotoxic activity |
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