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Hypervalent Iodine(III) Sulfonate Mediated Synthesis of Quinoxalines in Liquid PEG‐400 |
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| Authors: | Pei‐Ying Lin Rei‐Sheu Hou Huey‐Min Wang Iou‐Jiun Kang Ling‐Ching Chen |
| Affiliation: | 1. Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.;2. Chung Hwa University of Medical Technology, Tainan 717, Taiwan, R.O.C.;3. Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, R.O.C. |
| Abstract: | PEG‐400[poly(ethylene glycol‐400)] is used as a “green” recyclable solvent in the one‐pot synthesis of quinoxalines by reaction with aryl ketones, hypervalent Iodine(III) Sulfonate, and o‐phenylenediamines. Significant rate enhancements and improved yields have been observed. |
| Keywords: | Hypervalent iodine Quinoxalines Poly(ethylene golycol) |