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Syntheses of 5‐Chlorouracils/Thymines with 1‐[Phosphono(Methyl/Difluoromethyl)]‐1,2‐Unsaturated‐Moiety‐Substituted Methyl Groups at N(1) and Human Thymidine Phosphorylase Inhibitory Activity |
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| Authors: | Matthew?R Birck Keith Clinch Graeme?J Gainsford Vern?L Schramm Peter?C Tyler |
| Institution: | 1. Department of Biochemistry, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA (phone: +64‐4‐931‐3261;2. fax: +64‐4‐931‐3055);3. Present address: Homeland Security, 1100 Raymond Blvd., Newark, NJ 07120, USA.;4. Carbohydrate Chemistry Team, Industrial Research Ltd., P.O. Box 31‐310, Lower Hutt 5040, New Zealand |
| Abstract: |  |
| Keywords: | Thymidine phosphorylase inhibitory activity Uracil Thymine Inhibitors Nucleoside phosphonate analogs Phosphonates α α ‐difluoroalkyl Mitsunobu reaction Michaelis– Arbuzov reaction Nucleosides |