Synthesis and Biological Activity Evaluation of Novel Imidazolidinedione Derivatives,as Potent Antidiabetic Agent |
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| Authors: | Run‐Ling Wang Wen‐Ming Li Meng‐Yuan Liu Wei‐Ren Xu |
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| Institution: | 1. School of Pharmacy, Tianjin Medical University, Tianjin 300070, P. R. China;2. Tianjin Key Lab of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, P. R. China |
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| Abstract: | A set of novel imidazolidinedione derivatives were synthesized and evaluated as potential antidiabetic agents. Imidazolidinedione scaffold‐based molecules were synthesized and validated on a mice hyperglycemia model caused by alloxan. As a result, three of them showed antihyperglycemic activities. This research provides useful clues for further design and discovery of antidiabetic agents. |
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| Keywords: | Diabetes Antidiabetic agent Insulin resistance Imidazolidinedione derivatives |
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