Triumfettosterol Id and Triumfettosaponin,a New (Fatty Acyl)‐Substituted Steroid and a Triterpenoid ‘Dimer’ Bis(β‐D‐glucopyranosyl) Ester from the Leaves of Wild Triumfetta cordifolia A. Rich. (Tiliaceae) |
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| Authors: | Louis Pergaud?Sandjo Ingrid Konga?Simo Victor Kuete Paul Hannewald Mehdi Yemloul Vincent Rincheval Bonaventure Tchaleu?Ngadjui Gilbert Kirsch François Couty Serge Schneider |
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| Institution: | 1. Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon;2. Laboratoire d'Ingénierie Moléculaire et Biochimie Pharmacologique, Institut Jean Barriol, University of Paul‐Verlaine Metz, 1Bld Arago, F‐57070 Metz;3. Department of Organic Chemistry, University of Dschang, P.O. Box 67 Dschang, Cameroon;4. Department of Biochemistry, University of Dschang, P.O. Box 67 Dschang, Cameroon;5. Laboratoire de Spectrométrie de Masse et de Chimie Laser, Institut Jean Barriol, University of Paul‐Verlaine Metz, 1Bld Arago, F‐57070 Metz;6. Laboratoire de Méthodologie RMN, Institut Jean Barriol, University Henri Poincaré, Faculty of Science, P.O. Box 239, F‐54506, Vandoeuvre‐les‐Nancy Cedex;7. Laboratoire de génétique et biologie cellulaire, University of Versailles‐St‐Quentin‐en‐Yvelines, Batiment Fermat – Maison 4;8. Niveau 2;9. 45, avenue des Etats‐Unis, F‐78035 Versailles Cedex;10. Institut Lavoisier de Versailles UMR 8086 University of Versailles‐St‐Quentin‐en‐Yvelines, 45 Avenue des Etats‐Unis, F‐78035 Versailles Cedex;11. Laboratoire National de Santé, Division de Toxicologie, University of Luxembourg, 162a, Avenue de la Fa?encerie L‐1511, Luxembourg |
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| Abstract: | Two new triterpenoid derivatives were isolated from the leaves of wild Triumfetta cordifolia A. Rich . and identified to be a (fatty acyl)‐substituted steroid 1 and a triterpenoid saponin ‘dimer’ 2 , named (3β)‐stigmasta‐5,22‐diene‐3,29‐diol 3‐propanoate 29‐triacontanoate and (2α,3β,19α)‐2,3,19‐trimethoxyurs‐12‐ene‐24,28‐dioic acid 24‐(2α,3β)‐24,28‐bis(β‐D ‐glucopyranosyloxy)‐2‐hydroxy‐24,28‐dioxours‐12‐en‐3‐yl] ester, respectively. These compounds were obtained together with a mixture of known sterols (stigmasterol/β‐sitosterol=(3β,22E)‐stigmasta‐5,22‐dien‐3‐ol/(3β)‐stigmast‐5‐en‐3‐ol) and trans‐tiliroside ( 3 ). The structures 1 and 2 were determined on the basis of NMR data (1H‐, 13C‐, and 2D‐NMR analyses) and mass spectrometry and confirmed by chemical transformations. The antimicrobial activities of trans‐tiliroside ( 3 ) against eight bacterial and two fungal strains were evaluated. This compound showed weak activities on some bacterial strains. |
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| Keywords: | Triumfetta cordifolia Triumfettosterol Id Triumfettosaponin Steroids Triterpenoids Antimicrobial activity |
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