Barbatusin and cyclobutatusin,two novel diterpenoids from coleus barbatus bentham |
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| Authors: | Raymond Zelnik David Lavie Elie C Levy Andrew H-J Wang Iain C Paul |
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| Institution: | 1. Department of Organic Chemistry, Institute Butantan, São Paulo, Brasil;2. Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel;3. Department of Chemistry, University of Illinois, Urbana, IL 61801, U.S.A. |
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| Abstract: | The structure of three diterpenoids from Coleus barbatus, Bentham (Labiatae) having a spirocyclopropyl side chain have been determined: they are barbatusin (1a), 3β-hydroxy-3-deoxybarbatusin (2) and cyclobutatusin (3a). The structures of 1a and 3a were established by X-ray diffraction analysis, and the latter compound has been shown to have an unusual 4-membered ring produced by a bond across C(1) to C(11). Chemical transformations and interconversions are presented, together with spectroscopic studies. |
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