Deracemisation of aryl substituted α-hydroxy esters using Candida parapsilosis ATCC 7330: effect of substrate structure and mechanism |
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| Authors: | B Baskar NG Pandian K Priya Anju Chadha |
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| Institution: | aLaboratory of Bioorganic Chemistry, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600 036, India |
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| Abstract: | Candida parapsilosis ATCC 7330 was found to be an efficient biocatalyst for the deracemisation of aryl α-hydroxy esters (65–85% yield and 90–99% ee). A variety of aryl and aryl substituted α-hydroxy esters were synthesized to reflect steric and electronic effects on biocatalytic deracemisation. The mechanism of this biocatalytic deracemisation was found to be stereoinversion. |
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| Keywords: | Deracemisation Chiral HPLC Candida parapsilosis ATCC 7330 Stereoinversion Alpha hydroxy esters |
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