Stereoselective synthesis of the 6,6-spiroketal core of CP-61,405 (routiennocin) |
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| Authors: | Luiz C. Dias,Valquí rio G. Correia,Fernanda G. Finelli |
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| Affiliation: | Instituto de Química, Universidade Estadual de Campinas, UNICAMP C.P. 6154, 13084-971, Campinas, SP, Brazil |
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| Abstract: | A convergent and efficient synthesis of the 6,6-spiroketal core of the ionophore antibiotic CP-61,405 (routiennocin) is described. The synthesis required 10 steps from N-propionyl oxazolidinone (S)-8 and produced the desired spiroketal in 36% overall yield. |
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| Keywords: | Spiroketal Ionophore antibiotic Aldol reaction |
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