One step cascade synthesis of 4,5-disubstituted-1,2,3-(NH)-triazoles |
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| Authors: | Sengupta Sujata Duan Haifeng Lu Weibing Petersen Jeffrey L Shi Xiaodong |
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| Affiliation: | C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506, USA. |
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| Abstract: | A Lewis base-catalyzed three-component cascade reaction was developed for the synthesis of 4,5-disubstituted-1,2,3-(NH)-triazoles. More than 25 new (NH)-triazoles were prepared in good to excellent yields under mild conditions. The availability of the C-4 vinyl group allows easy conversion into other triazole derivatives. |
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