Palladium‐Catalyzed ortho‐Selective C?H Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles |
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Authors: | Sandy Ma Giorgio Villa Peter S Thuy‐Boun Anna Homs Jin‐Quan Yu |
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Abstract: | We disclose a protocol for the palladium‐catalyzed ortho‐selective C H deuteration of arenes. Phenylacetic acids and benzoic acids are suitable substrates for this reaction. This reaction offers a catalytic route to ortho‐deuterated phenylacetic acids and benzoic acids and demonstrates the sharp difference in reactivity of palladacycle intermediates held together by weak and strong coordination. |
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Keywords: | C‐H‐Aktivierung Deuterierungen Palladium Phenylessigsä ure Schwache Koordination |
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