Catalytic,Enantioselective Synthesis of 1,2‐anti‐Diols by Asymmetric Ring‐Opening/Cross‐Metathesis |
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Authors: | John Hartung Robert H Grubbs |
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Abstract: | An enantioselective method for the synthesis of 1,2‐anti‐diols has been developed. A cyclometalated chiral‐at‐ruthenium complex catalyzes the asymmetric ring‐opening/cross‐metathesis of dioxygenated cyclobutenes, thus resulting in functionally rich synthetic building blocks. Syntheses of the insect pheromone (+)‐endo‐brevicomin and monosaccharide ribose demonstrate the synthetic utility of the 1,2‐anti‐diol fragments generated in the title reaction. |
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Keywords: | Alkohole Asymmetrische Katalyse Metathese Pheromone Ruthenium |
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