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Palladium‐Catalyzed Synthesis of Phenanthridine/Benzoxazine‐Fused Quinazolinones by Intramolecular CH Bond Activation |
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| Authors: | Puneet K Gupta Nisha Yadav Subodh Jaiswal Mohd Asad Dr Ruchir Kant Dr Kanchan Hajela |
| Institution: | 1. Division of Medicinal and Process Chemistry, CSIR‐Central Drug, Research Institute, BS‐10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031 (India), Fax:(+91)?522‐2623405, ‐2623938;2. Molecular and Structural Biology Division, CSIR‐Central Drug Research Institute, BS‐10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031 (India) |
| Abstract: | A highly efficient synthesis of phenanthridine/benzoxazine‐fused quinazolinones by ligand‐free palladium‐catalyzed intramolecular C?H bond activation under mild conditions has been developed. The C?C coupling provides the corresponding N‐fused polycyclic heterocycles in good to excellent yields and with wide functional group tolerance. |
| Keywords: | C C coupling C H activation fused‐ring systems heterocycles oxidation |