Peptide δ‐Turn: Literature Survey and Recent Progress |
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| Authors: | Prof. Claudio Toniolo Dr. Marco Crisma Prof. Alessandro Moretto Dr. Cristina Peggion Prof. Fernando Formaggio Prof. Carlos Alemán Prof. Carlos Cativiela Prof. Chandrasekharan Ramakrishnan Prof. Padmanabhan Balaram |
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| Affiliation: | 1. ICB, Padova Unit, CNR, Department of Chemistry, University of Padova, 35131 Padova (Italy);2. Departament d'Enginyeria Quimica, ETSEIB, Universitat Politècnica de Catalunya, 08028 Barcelona (Spain);3. Department of Organic Chemistry, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), CSIC ‐ Universidad de Zaragoza, 50009 Zaragoza (Spain);4. Molecular Biophysics Unit, Indian Institute of Science, 0091 Bangalore (India) |
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| Abstract: | Among the various types of α‐peptide folding motifs, δ‐turn, which requires a central cis‐amide disposition, has been one of the least extensively investigated. In particular, this main‐chain reversal topology has been studied in‐depth neither in linear/cyclic peptides nor in proteins. This Minireview article assembles and critically analyzes relevant data from a literature survey on the δ‐turn conformation in those compounds. Unpublished results from recent conformational energy calculations and a preliminary solution‐state analysis on a small model peptide, currently ongoing in our laboratories, are also briefly outlined. |
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| Keywords: | cis‐amide conformational analysis peptides statistical analysis X‐ray diffraction |
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