Palladium‐Catalyzed C(sp3)H Arylation of N‐Boc Benzylalkylamines via a Deprotonative Cross‐Coupling Process |
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Authors: | Dr Nusrah Hussain Byeong‐Seon Kim Prof Patrick J Walsh |
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Institution: | Department of Chemistry, University of Pennsylvania, 231 S, 34th St. Philadelphia, PA 19104 (USA) http://titanium.chem.upenn.edu/walsh/index.html |
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Abstract: | Diarylmethylamines are key intermediates and products in the pharmaceutical industry. Herein we disclose a novel method toward the synthesis of these important compounds via C?H functionalization. Presented is a reversible deprotonation of N‐Boc benzylalkylamines at the benzylic C?H with in situ arylation by a NiXantPhos‐based palladium catalyst (50–93 % yield, 29 examples). The method is also successful with N‐Boc‐tetrahydroisoquinolines. The advantages of this method are it avoids strong bases, low temperatures, and the need to transmetallate to main group metals for the coupling. |
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Keywords: | C H functionalization cross‐coupling diarylmethylamines NiXantPhos ligand pallladium |
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