Unexpectedly Simple Synthesis of Benzazoles by tBuONa‐Catalyzed Direct Aerobic Oxidative Cyclocondensation of o‐Thio/Hydroxy/Aminoanilines with Alcohols under Air |
| |
| Authors: | Xinkang Shi Junmei Guo Dr Jianping Liu Prof Mingde Ye Prof?Dr Qing Xu |
| |
| Institution: | Zhejiang Key Laboratory of Carbon Materials, College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035 (P. R. China) |
| |
| Abstract: | tBuONa‐catalyzed direct aerobic oxidative cyclocondensation reactions of readily available alcohols and o‐thio/hydroxy/aminoanilines under air have been developed and provide an efficient, practical, and green method for the synthesis of benzazoles. Mechanistic studies revealed that o‐substituted anilines promote the initial aerobic alcohol‐oxidation step, which explains the high reactivity and success of this unexpectedly simple and practical cyclocondensation method. |
| |
| Keywords: | aerobic oxidation alcohols cyclocondensation green chemistry nitrogen heterocycles |
|
