BODIPY: A Highly Versatile Platform for the Design of Bimodal Imaging Probes |
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Authors: | Dr. Damien Lhenry Dr. Manuel Larrouy Dr. Claire Bernhard Dr. Victor Goncalves Dr. Olivier Raguin Dr. Peggy Provent Dr. Mathieu Moreau Dr. Bertrand Collin Dr. Alexandra Oudot Dr. Jean‐Marc Vrigneaud Dr. François Brunotte Dr. Christine Goze Prof. Franck Denat |
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Affiliation: | 1. ICMUB UMR6302, CNRS, Université Bourgogne Franche‐Comté, 9, avenue Alain Savary, 21078 Dijon (France);2. Oncodesign, 20 rue Jean Mazen, BP27627, 21076 Dijon Cedex (France);3. Centre Georges Fran?ois Leclerc, Service de médecine nucléaire 1 rue Professeur Marion, BP77980, 21079 Dijon Cedex (France) |
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Abstract: | In molecular imaging, multimodal imaging agents can provide complementary information, for improving the accuracy of disease diagnosis or enhancing patient management. In particular, optical/nuclear imaging may find important preclinical and clinical applications. To simplify the preparation of dual‐labeled imaging agents, we prepared versatile monomolecular multimodal imaging probe (MOMIP) platforms containing both a fluorescent dye (BODIPY) and a metal chelator (polyazamacrocycle). One of the MOMIP was conjugated to a cyclopeptide (i.e., octreotide) and radiolabeled with 111In. In vitro and in vivo studies of the resulting bioconjugate were conducted, highlighting the potential of these BODIPY‐based bimodal probes. This work also confirmed that the biovector and/or the bimodal probes must be chosen carefully, due to the impact of the MOMIP on the overall properties of the resulting imaging agent. |
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Keywords: | BODIPY imaging agents macrocycles molecular imaging optical imaging positron emission tomography |
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