Exploiting the Brønsted Acidity of Phosphinecarboxamides for the Synthesis of New Phosphides and Phosphines |
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Authors: | Andrew R Jupp Gemma Trott Éléonore Payen?de?la?Garanderie James D G Holl Dr Duncan Carmichael Prof?Dr Jose M Goicoechea |
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Institution: | 1. Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA (UK);2. Laboratoire de Chimie Moléculaire, école Polytechnique, CNRS, 91128 Palaiseau cedex (France) |
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Abstract: | We demonstrate that the synthesis of new N‐functionalized phosphinecarboxamides is possible by reaction of primary and secondary amines with PCO? in the presence of a proton source. These reactions proceed with varying degrees of success, and although primary amines generally afford the corresponding phosphinecarboxamides in good yields, secondary amines react more sluggishly and often give rise to significant decomposition of the 2‐phosphaethynolate precursor. Of the new N‐derivatized phosphinecarboxamides available, PH2C(O)NHCy (Cy=cyclohexyl) can be obtained in sufficiently high yields to allow for the exploration of its Brønsted acidity. Thus, deprotonating PH2C(O)NHCy with one equivalent of potassium bis(trimethylsilyl)amide (KHMDS) gave the new phosphide PHC(O)NHCy]?. In contrast, deprotonation with half of an equivalent gives rise to P{C(O)NHCy}2]? and PH3. These phosphides can be employed to give new phosphines by reactions with electrophiles, thus demonstrating their enormous potential as chemical building blocks. |
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Keywords: | anions carboxamides phosphides phosphines phosphorus |
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