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No-solvent Condensation Reaction of Amino Acids and their Derivatives with Pyrandione
Authors:Qiang JIA  Zheng Ming LI  Su Hua WANG  Wei Guang ZHAO  You Ming WANG Institute of Elemento-Organic Chemistry  Nankai University  Tianjin
Affiliation:Qiang JIA,Zheng Ming LI*,Su Hua WANG,Wei Guang ZHAO,You Ming WANG Institute of Elemento-Organic Chemistry,Nankai University,Tianjin 300071
Abstract:Synthesis of a novel series of N-pyrandione substituted amino acids and their esters 3 via a condensation reaction between pyrandione and amino acid or their derivatives in excess ethyl orthoformate without solvent is described. The stereochemistry of 3 has been discussed.
Keywords:Pyrandione   amino acid   condensation reaction   Z/E isomer   green chemistry.
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