A novel palladium catalyst for the amination of electron-rich indole derivatives |
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| Authors: | Nicolle Schwarz |
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| Affiliation: | Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, D-18059 Rostock, Germany |
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| Abstract: | The palladium-catalyzed amination of a 3-silyloxy-substituted bromo-indole with primary and secondary amines is described for the first time. In the presence of the novel catalyst system of Pd(OAc)2/N-phenyl-2-(di-1-adamantylphosphino)pyrrole potentially bioactive amino-functionalized indole derivatives are obtained in a general manner in high yield. |
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| Keywords: | Amination C-N coupling Palladium Indoles |
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