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Synthesis of 5-heteroarylazulenes: first selective electrophilic substitution at the 5-position of azulene |
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| Authors: | Taku Shoji Shunji Ito Kozo Toyota Noboru Morita |
| Institution: | a Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan b Department of Frontier Materials Chemistry, Faculty of Science and Technology, Hirosaki University, Hirosaki 036-8561, Japan c Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai 980-8577, Japan d Department of Materials Chemistry and Engineering, College of Engineering, Nihon University, Koriyama 963-8642, Japan |
| Abstract: | 1,3-Di-tert-butylazulene reacted with highly electrophilic trifluoromethanesulfonate of N-containing heterocycles to give 5-(dihydroheteroaryl)azulene derivatives in good yield and treatment of the 5-(dihydroheteroaryl)azulene derivatives with KOH afforded 5-(heteroaryl)azulenes in excellent yield. |
| Keywords: | Azulene Heterocycle Electrophilic substitution |
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