An efficient and versatile route to the synthesis of 9,10-dihydro-3-formylphenanthrenes |
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Authors: | Ramendra Pratap |
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Affiliation: | Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India |
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Abstract: | An innovative and efficient route to the synthesis of 9,10-dihydro-3-formylphenanthrenes 7 has been delineated through the ring transformation of 2-oxo-4-sec-amino-5,6-dihydro-2H-benzo[h]chromene-3-carbonitriles 4 with methyl glyoxaldimethylacetal 5 to masked 3-dimethoxymethyl-1-sec-amino-9,10-dihydrophenanthrene-3-carbonitriles 6 followed by deacetalation with Amberlyst 15 in excellent yields. |
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Keywords: | Tetralone Formylphenanthrene 2-Oxo-4-sec-amino-5,6-dihydro-2H-benzo[h]chromene-3-carbonitriles Masked aldehyde Ring transformation |
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