Stereoselective synthesis of the C31-C39 unit of (+)-phorboxazoles from m-anisaldehyde |
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Authors: | S. Praveen Kumar |
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Affiliation: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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Abstract: | A stereoselective route for the synthesis of the C31-C39 fragment of (+)-phorboxazoles is described. The route features Birch reduction, ozonolysis and acid-catalysed cyclisation of enantiopure precursors as key transformations to give the tetrahydropyran ring, starting from m-anisaldehyde as a masked β-keto ester to obtain the pyran skeleton of compound 1. |
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