Enantioselective organocatalytic aryloxylation of aldehydes with o-quinones |
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Authors: | Felix A Hernandez-Juan |
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Institution: | School of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, UK |
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Abstract: | An enantioselective organocatalytic inverse electron demand hetero Diels-Alder reaction of in situ generated enamines with o-quinone reagents is reported. The method, which is optimal in wet acetonitrile at ambient temperature, provides a new and direct asymmetric route to the aryl alkyl ether motif and an alternative metal-free strategy to SN2 substitutions with phenolate nucleophiles. |
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Keywords: | Enantioselective organocatalysis Enamine o-Quinone Diels-Alder Aryloxylation |
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