A one-pot synthesis of 3-substituted-5-carbonylmethyl-1,2,4-oxadiazoles from β-keto esters and amidoximes under solvent-free conditions |
| |
| Authors: | Wu Du Quang Truong Hongbo Qi Yan Guo Harry R Chobanian William K Hagmann Jeffrey J Hale |
| |
| Institution: | Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA |
| |
| Abstract: | Herein we report a high yielding one-pot ‘green’ synthesis of 3-substituted-5-carbonylmethyl-1,2,4-oxadiazoles from readily available β-keto esters and amidoximes under simple and convenient solvent-free conditions. No additional base is needed. The reaction likely goes through an acyl ketene intermediate. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
