The first application of an imidazole o-quinodimethane in Diels-Alder reactions leading to the synthesis of benzimidazoles |
| |
| Authors: | Constantinos Neochoritis |
| |
| Affiliation: | Department of Chemistry, Laboratory of Organic Chemistry, University of Thessaloniki, 54124 Macedonia, Greece |
| |
| Abstract: | An efficient procedure for the generation of the imidazole-4,5-quinodimethane intermediate 4 from 2-bromo-4,5-bis(bromomethyl)imidazole derivative 3 in boiling toluene in the presence of 18-crown-6 is described. o-Quinodimethane 4 was captured for the first time by several symmetrically and unsymmetrically substituted dienophiles to afford the corresponding Diels-Alder benzimidazole adducts. |
| |
| Keywords: | Imidazole o-quinodimethanes Benzimidazoles Diels-Alder reactions |
| 本文献已被 ScienceDirect 等数据库收录！ |
