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Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana |
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| Authors: | Shih-Chang Chien Ching-Chuan Kuo Ning-Sun Yang |
| Affiliation: | a Department of Chemistry, National Taiwan University, Taipei 106, Taiwan b Division of Cancer Research, National Health Research Institutes, Taipei 114, Taiwan c Division of Hematology/Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan d Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114, Taiwan e Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan f College of Pharmacy, China Medical University, Taichung 404, Taiwan g Research Center of Food and Biomolecules, College of Bioresources and Agriculture, National Taiwan University, Taipei 106, Taiwan |
| Abstract: | The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.02.6]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against several human cancer cells with IC50 values ranging from 0.19 to 0.52 μM, whereas 4 has no activity. |
| Keywords: | Chamaecyparis obtusa var. formosana Dimer of monoterpene and norlignan Norlignan |
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