1,2-Bis(2,5-diphenylphospholano)methane, a new ligand for asymmetric hydrogenation |
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| Authors: | Mark Jackson Ian C. Lennon |
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| Affiliation: | Dowpharma, Chirotech Technology Ltd, a subsidiary of The Dow Chemical Company, Unit 162 Cambridge Science Park, Milton Road, Cambridge CB4 0GH, UK |
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| Abstract: | 1,2-Bis(2,5-diphenylphospholano)methane (Ph-BPM) has been prepared in good yield from 2,5-trans-diphenylphospholane-borane adduct. Rhodium and ruthenium complexes of this ligand have been prepared and their usefulness in asymmetric hydrogenation has been investigated. [Ph-BPM Rh(COD)]BF4 showed high activity and selectivity for itaconate and dehydroamino acid hydrogenation. Ph-BPM RuCl2(DPEN) was effective for imine hydrogenation. |
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| Keywords: | Rhodium Asymmetric catalysis Hydrogenation Phospholane |
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