Synthesis of 5(6)-dihydro-OSW-1 by using the intact skeleton of tigogenin |
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| Authors: | Li-Jun Chen Hao Huang Wei-Sheng Tian |
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| Institution: | a The Laboratory of Resource Chemistry, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, PR China
b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, PR China |
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| Abstract: | 5(6)-Dihydro-OSW-1 (1), an analogue of OSW-1 with the potent anticancer activity, was synthesized by utilizing the intact skeleton of tigogenin in 13 steps in 9.0% overall yield. This synthesis demonstrated an effective and reasonable synthetic strategy for bioactive steroids with side chains as compared with their routine synthesis. |
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