An efficient synthesis of (+)-decursinol from umbelliferone |
| |
Authors: | Jung Ho Lee |
| |
Affiliation: | Department of Chemistry and Institute of Applied Chemistry, Hallym University, Chunchon 200-702, Republic of Korea |
| |
Abstract: | An efficient, practical and enantioselective total synthesis of (+)-decursinol, which has diverse range of biological properties including anti-cancer, anti-Helicobacter pylori, and strong antinociceptive activities, has been achieved in five steps with 41.4% overall yield from umbelliferone. The improved ring construction from coumarin to linear pyranocoumarin has been obtained through quinonemethide intermediate by using phenylboronic acid with propionic acid. |
| |
Keywords: | Decursinol Umbelliferone Coumarin Quinonemethide Phenylboronic acid |
本文献已被 ScienceDirect 等数据库收录! |
|