|
|||||
|
|
New practical access to 2-azatryptophans and dehydro derivatives via the Wittig-Horner reaction |
|
| Authors: | François Crestey Silvia Stiebing Jean-François Lohier Jana Sopkova-de Oliveira Santos Sylvain Rault |
| Institution: | Centre d’Etudes et de Recherche sur le Médicament de Normandie (CERMN), UPRES EA-3915, U.F.R. des Sciences Pharmaceutiques, Université de Caen Basse-Normandie 5, rue Vaubénard 14032 CAEN Cedex, France |
| Abstract: | The Wittig-Horner reaction of protected 3-formylindazoles 1 with (±)-N-(benzyloxycarbonyl)-α-phosphonoglycine trimethyl ester 2 has been developed as a new practical synthesis of dehydro 2-azatryptophans and amino acid derivatives. The preparation of 5-bromo-3-formylindazole is discussed. |
| Keywords: | Amino acid derivatives Indazole Dehydro 2-azatryptophans Wittig-Horner reaction 3-Formylindazoles Weinreb amides |
| 本文献已被 ScienceDirect 等数据库收录！ | |