Efficient synthesis of 3-oxygenated benzothiophene derivatives |
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| Authors: | Fuyao Zhang David Mitchell Patrick Pollock Tony Y. Zhang |
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| Affiliation: | Chemical Product R&D, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA |
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| Abstract: | An efficient synthesis of 2-bromo-3-aryloxybenzothiophene derivatives by a conjugate addition-elimination sequence of 2,3-dibromo benzothiophene dioxides with phenolic nucleophiles has been developed. These benzothiophene derivatives serve as important intermediates for the synthesis of SERM analogues. |
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