Synthesis of substituted butenolides by the ring closing metathesis of two electron deficient olefins: a general route to the natural products of paraconic acids class |
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Authors: | N. Selvakumar P. Kalyan Kumar K. Chandra Shekar Reddy B. Chandra Chary |
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Affiliation: | Department of Discovery Chemistry, Discovery Research, Dr. Reddy’s Laboratories Ltd., Miyapur, Hyderabad 500 049, India |
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Abstract: | A variety of allyl acrylates possessing electron-withdrawing groups undergo RCM using the second generation Grubbs’ catalyst in the presence of a Lewis acid resulting in diverse butenolides in high isolated yields. This methodology provides a general route to the natural products of paraconic acids class, exemplified by a total synthesis of (±)-phaseolinic acid. |
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Keywords: | Ring closing metathesis Baylis-Hillman reaction |
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