Novel synthesis of 3-(3,3,3-trifluoroprop-1-en-2-yl)furans via stereoselective processing and palladium-catalyzed cycloisomerization |
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| Authors: | Jiming Zhang |
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| Institution: | Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, PR China |
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| Abstract: | The 3,3,3-trifluoroprop-1-en-2-yl-substituted furans (4) were synthesized via palladium-catalyzed cyclization-isomerization of 1,1,1-trifluoro-2-(tert-butyldimethylsilyloxy)methyl]-3-alkynylbut-2-en-1-ols (3), which were readily obtained from 1,1,1-trifluoro-2-(tert-butyldimethylsilyloxy)methyl]-3,3-dibromoprop-2-ene (1) in three steps. |
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| Keywords: | Trifluoromethyl Palladium Cyclization-isomerization Furan |
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