Reversed-phase ion-pair liquid chromatographic method for the determination of low concentrations of haloperidol in plasma |
| |
| Authors: | L B Nilsson |
| |
| Affiliation: | Astra Research Center, S?dert?lje, Sweden. |
| |
| Abstract: | A sensitive liquid chromatographic method for the determination of haloperidol in plasma is described. The efficient and simple extraction procedure, followed by reversed-phase ion-pair liquid chromatography on a 3-micron octadecylsilica column and UV absorbance detection, makes it possible to determine concentrations down to 0.5 nmol/l with acceptable precision. In a pharmacokinetic study, in which 5 mg of haloperidol were given orally, the plasma levels were followed for 48 h. |
| |
| Keywords: | |
|
|
