Chemoenzymatic synthesis of both enantiomers of cispentacin |
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| Authors: | Fritz Theil Sibylle Ballschuh |
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| Affiliation: | Institut für Angewandte Chemie Berlin-Adlershof, D-12484 Berlin, Rudower Chaussee 5, Germany,Fax +(030) 63924103; |
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| Abstract: | Based on the lipase-catalysed kinetic resolution of the silyloxyalcohol (1RS,2SR)-5 by transesterification with vinyl acetate in the presence of lipase from Pseudomonas cepacia a synthesis of both enantiomers of the β-amino acid cispentacin (1R,2S)-1 and (1S,2R)-1 using simple functional group interconversions is described. |
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