A mechanistic model for the metabolism of corrosion products and of biological trace elements in metallosis tissue based on results obtained by activation analysis

Instrumental neutron activation analyses have been carried out on tissues adjacent and distant from metal implants. From the time-dependence of the concentrations of the corrosion products some conclusions have been drawr on the routes of metal transport from the implant. Additionally, the behaviour of haematoma iron has been shown as well as the dependence of the zinc concentrations on different biochemical processes, during implantation and then at the following stages of the development of the metallosis tissue. This work was supported by the Bundesministerium für Forschung und Technologie, the Deutsche Forschungsgemeinschaft, and the Fonds der Chemischen Industrie.