Catalytic asymmetric synthesis of axially chiral o-iodoanilides by phase-transfer catalyzed alkylations |
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Authors: | Shirakawa Seiji Liu Kun Maruoka Keiji |
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Affiliation: | Laboratory of Synthetic Organic Chemistry, Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan. |
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Abstract: | Catalytic asymmetric synthesis of axially chiral o-iodoacrylanilides and N-allyl-o-iodoanilides as useful chiral building blocks was achieved via chiral quaternary ammonium salt-catalyzed N-alkylations under phase-transfer conditions. The transition-state structure for the present reaction is discussed on the basis of the X-ray crystal structure of ammonium anilide. |
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