4-hydroxy-2-quinolones. 96. Synthesis and properties of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid |
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| Authors: | I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova S. V. Shishkina |
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| Affiliation: | (1) National Pharmaceutical University, Kharkov, 61002, Ukraine;(2) Institute of Scintillation Compounds, National Academy of Sciences of Ukraine, Kharkov, 61001 |
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| Abstract: | Alkaline hydrolysis of the ethyl ester of 4-(cyanoethoxycarbonylmethyl)-2-oxo-1,2-dihydroquinoline-3-carboxylic acid is accompanied by decarboxylation with loss of two molecules of CO2 and leads to 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 887–893, June, 2006. |
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| Keywords: | 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid cyanoacetic ester, 4-chloroquinoline amidation hydrolysis decarboxylation X-ray structural analysis |
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